![]() There is overwhelming evidence that the development of microvascular complications is related to the level of glucose dysregulation over a long period of time. Peripheral neuropathy can present as tingling, burning, pain, cramps, paresthesia, or numbness. Neuropathy is a microvascular complication of diabetes mellitus which leads to considerable morbidity and a decreased quality of life. Study selection and quality assessment were performed independently by three observers. ![]() Randomised controlled trials using the TSS score as the outcome measure were selected and assessed for their methodological quality. ![]() We performed a systematic review of the literature to evaluate the effects of alpha lipoic acid for symptomatic peripheral neuropathy in patients with diabetes mellitus.
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